I use around 36 grains of Varget for 139-140 grain bullets for C, P & T, with a muzzle velocity around 2,500 fps and 40.5 grains of Varget with Sierra 168 HPBT's for the rams at 500 meters, with a muzzle velocity of about 2,550 fps.
Both loads are easy on the shoulder and have yet to leave anything hit standing.