This is just IMHO, but due to a bit of on the job experience gathered over the years, GO WITH THE FAILSAFE!!!!
In less Sierria has started to make a premimun level bullet that I haven't heard about, they are still a cup & core design.
Not to say they won't shoot and group good, but the Nosler Balistic Tip is know for shooting very well, but I wouldn't use them if I wasn't willing to except a fair amount of possible meat loss.
The Hornady interlock is a step above the cup and core type, and bigger is better, but it sure ain't a Nosler Partition.
Seems to me like there is no choice here. You have one for practice and one for hunting with the Failsafe, without question, being the very clear winner for the hunt.
Keep em coming!
CDOC