While I certainly agree with 454Puma that the Casull delivers a lot more kinetic energy at a longer range, I'm not sure that means much in the practical world. Years ago, when I used to teach a handgun hunting course, we impressed on our students not to shoot big game beyond 50 yards. The reason for this was not the lack of energy the gun delivered or the performance of bullets beyond that range, it was because the average man or woman couldn't shoot well enough with a handgun to insure a clean kill. Colorado used to require an examination of all would be handgun hunters in order to get a handgun hunting license. [They abolished that requirement about 15 years ago.] Among other things, the students had to put 6 rounds with their hunting handgun and hunting loads in a 6" disk, off-hand, at fifty yards. Back in the days when I was administering the test, I was always surprised by the fact that only about 10% of the applicants could pass that test. Part of the problem, of course, is that a LOT of hunting handguns are only capable of shooting 3"-4" at 50 yards from a bench and offhand adds error to that. Most guns had to be "tuned" for accuracy and it requires careful load development to get there along with a lot of disciplined practice. I don't do any handgun hunting anymore, and I rarely teach it -- getting too old I guess and I don't like packing elk out of the Colorado Mountains no matter how I kill it -- but I still think 50 yards is the limit for most handgun hunters.