If you place your shots well the 25-06 Remington will do the job every time with any bullet from 100 to 120 grains. Every cartridge made from the parent 30-06 Springfield is a smart choice.
I always shoot a double lung for deer or antelope and never a shoulder shot unless I am shooting bears then I want to break down both shoulders.
Antelope are very fun and easy to spot & stalk hunt with success rates in the 90% on public land.
I have used my 243 Winchester, 100 grain Nosler Partitions and IMR-4350 from 50 to 300 yards and they were all complete pass throughs and didn’t go more than 10-20 yards in Wyoming and New Mexico.
I have also hunted Mule deer with equal success in North Dakota with my 270 Winchester, 150 grain Hornady Interlock and IMR-4831.
This year I used my 338-06 A-Square for a nice doe whitetail to see how it worked, well perfect performance with complete pass through double lung and hear shot and no wasted shoulder meat. I used 30-06 Springfield brass, 200 grain Nosler/Winchester combined technology Silver Ballistic Tips and IMR-4320.
Varmints, I use the 223 Remington, for manly fox and coyotes which is more than enough for either, 45, 50 to 55 grain bullets, and IMR-3031 & H-4198. At longer ranges for coyotes, I use 22-250 Remington, 50 to 55 grain bullets, and IMR-4064 or 243 Winchester, 70, 75, 80 to 87 grain bullets and IMR-3031, IMR-4064 or IMR-4320, but both are overkill for any coyote out to 400 yards in my experience.
yooper77