I didn't want to come right out and say that the 357 Mag is inadequate to kill deer with when I first responded but I will say that at best it is a short range maybe clean killing tool for big game. It works fine on smaller critters and I have used both a handgun and rifle to shoot a lot of critters but I draw the line at deer and above unless the shooters is: 1. A real cool hunter who does not get buck fever, 2. Is a good shot, and 3. Will refuse a difficult shot rather than risk wounding an animal. Personally, when hunting big game (deer, elk, antelope, Sheep, Moose, bear and etc.) I generally stick to rifle calibers that have enough potency to blast through bone and still exit the animal. The reason for this is that I have had too many occations when conditions weren't optimum and I had to shoot the animal at less than an optimal angle. To date I have killed three big game animals with pistol caliber rifles and two with hand guns. All except one was taken at ranges under 50 yards and all but one required tracking the animal to a greater of lesser amount. There were no dead right there events. However. I have killed over 60 head of big game with an adequate rifle and none of the animals traveled more that 25 yards or so and most fell pretty close to where they were shot. You can call me fussy but I do not like to spend hours hunting in heavy cover for a downed deer that was shot with a marginal calliber.