Hands down THE powder for the 22/250 is H380. It was designed for this caliber!! 38Gr's and a 55Gr bullet makes for an excellent load!! THAT'S THE NAME IN THE CAN!!
For the 223 I really like another Hodgdon powder, H322 and a 52/53Gr match hollow point bullet sparked with a CCI BRII primer.
Good luck,
CW