Some folks think a .300 WM is much too harsh on the shoulder. I personally don't find that to be the case, as I compare it to my heavy .45-70 and myuzzleloader loads which generate considerably more recoil.
Although I haven't done anything with my .300 WM that I couldn't do with a .308 Win, if I knew ranges would be long my .300 WM would be the one I would go for.