A few years ago I built a 22-250 with a 1/9 twist ER Shaw barrel for shooting the smaller deer down in the Texas hill country. I wanted to shoot the larger 70 grain TSX bullets, but I could never get them to shoot all that well. I had a box of the .224 Nosler partitions that I like in my 222mag AI so I loaded some of them up and found a winning combination. Since then I have shot several deer with these and have yet to have a deer take a step. Heart/lung shots. Turned there insides to jelly.
Where I hunt now we have much bigger deer so I usually start my season with my 257AI and then after I get a buck I switch over to the 22-250 with the 60 grain partitions for does and spikes. Its pure poison on them if you pick your shots.