Over the years I have shot deer with the 22-250, 243, 257, 25-06, 264 , 270, and 308 Norma. All got the job done but My old Win Mdl 70 270 that I got in 1952 using 130 Gr bullet reloads is my favorite. That old 270 Win has shot pronghorn, mule deer, elk, and other unwanted critters . I ll be 75 years old before the 2010 fall deer season and the old 270 is what I ll be using.