gunther66, Welcome to the family of 43 Spanish Argentine Rolling Block Shooters. I've had one of them since the late 1960s. I don't shoot mine that much, but here are some suggestions if you wish to switch from black powder to smokeless. First, the published load data for the original antique trap door 45-70 rifles, or better yet the .43 Mauser, is pretty close to the proper load data for the 43 Spanish, so you can use it for a guide for reloading.
Heck, back in the late 60s I actually used to shoot 43 Mauser ammo, made in Canada for use in the 1871 Mauser, in my 43 Spanish RB. Something I certainly do not encourage you do, but it furnished me the brass needed for reloading.
Can't remember for sure what powder and load I used for 370 gr cast bullets back in the 60s, but it may have been 13gr of Unique. If it was Unique, then I had a hoot of a time shooting at a bank of sand in a creek several hundred yards away from. Shoot, set down rifle, pick up binoculars and wait for bullet to hit the bank of sand. You'd think I was firing a mortar the way I had rear sight raised up to shoot that distance with the load.
I got back into shooting/reloading about 5 years ago and now load my 370gr cast bullets with other smokeless powders/loads. Using load data from "Cartirdges of the World, I used 40 grains of IMRs 3031 powder with a 370 gr cast lead bullet, which should be OK for your 300 grain bullet.
My Lee reloading Manual shows for your 300 gr cast bullet:
40.5 gr of H4895 as a start load and 48.4 as max
27 gr of H4198 as a start load with 31.8 as max.
36 gr of Varget with 42.7 gr as max.
25.1 gr of Accurate XMP5744 as start and 29.4 as max.
Hodgdon 45-70 trap door data for the IMR Trail Boss powder is 14 gr start and 16.5 max. with the 300 gr cast bullet. This should be just fine with your RB.
So, smokeless powder data for the 43 Spanish RB is available.
I do recommend the XMP5744 or Trail Boss powders. Both are less case sensitive and better suited for the large brass case of the 43 Spanish.
By the way, your 43 Spanish caliber Rolling block should be the 1879 Argentines RBs. It was dumped in the U.S. market in the late 50s and 60s. LOL, I paid $35 for mine about 1967 and it was in mint condition.