I always zero with several factors in mind:
???The rifle's effective killing range of the animal hunted
???What is reasonalble concerning the trajectory
???What distance will most of the hunting shots be taken.
Examples: We hunt squirrels at reasonable close range, and the 100 yard drop is a little dramatic, so, I zero at 40 yards. Still good a reallty close shots and on out to 75 yards. I zero my .308 at 100 because I'll never see a deer further than that where I hunt. If I lived in more open country, I'd zero at 200.
I don't have a 45LC rifle yet, but I'd zero it at 75 yards. You could still hold dead on a deer-size animal at closer ranges, or hold on his back at extended distances.
45LC pistol. zero at 25 yards, becaue it is a close range weapon, but if I want to take a 50 yard shot, I still can without thinking about elevation.