I have taken several deer with my Ruger 350 Mag, using the Speer 220 gr FP bullet. MV has been around 2,560 fps with either IMR 4320 or H322. It was easy to find an accurate load with either powder and the 220 gr Speer. The ranges I've taken deer have been from 30 -120 yards. If the deer do manage to run after the shot, they don't go far and there has been for me a massive blood trail. I'm well pleased with this combo on deer. I can't say anything about what this would do to bear, since there are no bears where I hunt but I suspect it would work well. Congrats on a great rfile in a great caliber.