I shoot at deer with a my Ruger LC only if I can get within 25 yards, not for lack of stopping power, but because I'm afraid of a bad hit. All deer I've hit with 300 grn. hardcast over 2400 fell within sight. I honestly think that heavy and slow is the way to go for deer, even better than a 240 grn. JHP .44 Magnum. I've hunted with both, and with .357s, and 45acp, but have settled on the LC. This is going to sound silly, if not outright stupid, but if I collect my deer early in the day, I stay in the woods and shoot squirrels with the same load. Groups with that load are 1 3/8" at 25 yards. I think it'll do anything that needs doing.