I started with a Lee autoprime, and it worked fine, except I like to prime batches of 200-400 cases at a time. The autoprime uses only your thumb to actuate it, and my thumb would go numb before I was done.
I switched to RCBS univeral hand primer with the square tray. It uses the whole hand, and it much easier to load and use with its large, removable square tray. It isn't a cake walk to switch primer sizes with, so I kept the autoprime around setup for small primers (I use much less of those anyway). Then my wife bought me a second universal.
Andy