I reccomend the same weight and profile for both 44 and 45. Our WFN in 280 gr. Up the weight to 300 in 44, 325 in 45 if you live in big bear country or intend to hunt them with the handgun, and burn lots of powder for that purpose. But for any deer sized game almost all game hit reasonably well will go down in its tracks or within a few feet, if your bullets are started at a very pleasent to shoot 1200 fps, with either cartridge.
If you love high power and feel you need a flat trajectory, the LFN in the same weights may make you happier, loaded to the wall. Or load the WFN to full power if you like. It will perform extreemly well, but near instant kills with low recoil and noise shouldn't be overlooked by most shooters, in my opinion.