besides the heavy bolt you would have to design and manufacture, the heavier springs you would have to determine, there is the matter of is the action long enough for the increased stroke involved and is it strong enough, is there enough room on bottom of action to mill out for magnum magazine, would you have to move the stock mounting point to clear the longer mag which would involve cutting another notch in the barrel and using longer screws for the v-block and on it goes. the short point to this long story is sell your 10-22 and put the money toward a magnum. there are probably many more reasons that a more knowledgable person could point out to you. my opinion and you're welcome to it. good luck and have a good'en neighbor, bubba.