I would like to know who make a hand gun with lh controls and if you use a sig how do you work the RH safety and slide lock thanks.
CZ makes a few handguns with ambi controls. There are a lot of 1911s out there that have ambidextrous controls, and those that don't are easily convertible. Ruger semi-autos have ambidextrous safeties and decockers.
Depending on layout, I find that the safety is the only thing on a lot of guns that gives me any trouble as a lefty. An ambidextrous safety is obviously ideal, and a right-hand only safety can create some issues.
The location of the slide stop/release on 1911 style pistols (as well as the CZ pistols) is actually fairly lefty friendly and can easily be manipulated with the trigger finger (unlike the Sig, haven't found a good way to manipulate the slide release on a Sig left-handed). The magazine release can be manipulated with the trigger finger, though I find it more comfortable to use the middle finger for this task.