If you're looking for bigger holes, why not stay with .500 S&W or Freedom Arms .500 Wyoming Express or perhaps BFR's newer .50 caliber(I believe these are even bigger than the S&W bullets). As stated earlier in the thread, you can always load lower to suit yourself? And can always load for Tyrannosaurus Rex if you so desire? But, you must remember, bullet placement is key to any hunting success?
Steve