I shot the Hornady LE ammo too and it was accurate to 75yds, opening a bit more than I liked at 100yds, maybe 3-4". I have noticed a few things about my .45LC Handi; it shoots better with slow heavy bullets in the beginning and after about 200rds it starts to shoot the lighter bullets good too. Mine has liked the 360gr CPB at 1100fps and now also likes the factory Cor-Bon 225gr Barnes XPBs at 1300fps.
Give it time, it will settle in there for you.
Thanks, Dinny