I've loaded it for 12, 20 and 28 but have never even fired much less loaded for a 16 gauge. Still since it's used for those on both sides of it I see no reason why it shouldn't work for a 16 ga. Check with powder maker or get their free data book and likely loads will be found. If you don't have the latest Lyman Shotshell loading manual ya should get it. I'd never be without the latest one for my shotshell loading info.
I suppose if ya PM me with the hull, wad and shot weight you hope to use I can look thru mine for a load suggestion tho as I say if ya don't have the manual ya really shouldn't be reloading shotshells. It's that worthwhile.