If you really want to have fun and save your barrel and barrel heat and easy on brass and noise . you can down load that 22-250 to shoot velocity of 22 mag ,22Hornet to lower to mid 22-250 velocity,etc with blue dot loads ,you can get 400-500 loads per pound of powder.I burn a lot of it in 223 11 grains gives around 2500 with 55 grain bullet and 204 Ruger with 12 grains Bluedot and a 26 grain varmint grenade gives 3500+ they are a blast. I also use it in others also ,you all know how a 30-06 kicks and barks,I load a 160 grain lead cast fn with x grains of blue dot and my 9 year old shoots one of my 1918, 03 Springfield's with no trouble at all he would rather shoot that than his 204 ruger.I load these for general to small game shooting etc and plan to shoot at woods ranges and test all loads at 50 yards and have several from all the guns I load blue dot in that shoot 1 hole groups at 50 yards. I started these to make quiet loads to shoot in 30-30 and 30-06 to shoot coons in the garden and have had a blast with them.
THESE CAN BE VERY DANGEROUS they are not for the sloppy loader ,a double charge would be big trouble ,I have a pencil marked and gauge every case to double check before it gets a bullet.