Not to jack the thread, but I've been having the same problem with a particular load making two different groups, so I conducted an experiment.
I properly prepped the brass, trimmed, camfered, cleaned, etc.
I loaded the brass with exactly the same weight of powder, with four different bullets, from four manufacturers. (Speer, Hornady, Sierra, and Cast).
Three of the four loads fell into nice tight groups. The fourth one fell into two groups, three inches apart. Just like it had always done.
All I can deduce is that this particular barrel doesn't like that particular bullet. That's okay, because I have other rifles that love that particular bullet. They'll shoot it into MOA all day long. For some reason, this particular barrel won't shoot it. Lesson learned.