I have both in Handis. My .223, for accuracy, outshoots my .22-250....by a great deal. Both have had nothing but factory ammo thru them, as I haven't started reloading my necked cartridges yet. Yes, the .22-250 shoots longer, but misses. The .223 just doesn't retain accuracy or punch as far as I'd like, but it whacks anything within 300 yards. I'll be able to tell more in late August after I get back from a shoot and start tinkering with them. Just now, I've got about a thousand rounds to load by August 6th for Patty and this guy.
Pete