While cutting molds today I was pondering this post and the use of cerrosafe throat castings.
Nothing is better for checking the concintricity of a chamber/throat to the rifling and bore. Make the cast to include at least 1 1/2 inches of rifling and only a little throat is needed, but all the throat and part of the chamber is ok. Chuck the rifled portion in a lathe and use a dial indicator to be sure that portion is running dead true, or mark it's exact high and low spot, and amount of wobble the chuck is throwing into it. Then move your indicator to the throat/lead just before the rifling, (if the throat has a gentle taper) or with chamberings like the 45-70, 30-30 and similarly chambered rifles which have very abrupt chambers, set your indicator on the chamber neck area. If runout is more than .001, a bullet that is over groove diameter will be forced out of balance when fired, so make your bullets hard as possible and size them close as possible to groove diameter. This arangement almost always gives excellent accuracy, but as speeds are raised to the accuracy limit, expect some fliers. Not wild fliers, but group ruiners.
If chamber/throat runout is under .001, best accuracy will normally be obtained if that portion of the bullet held inside the case neck, and as far as possible into the throat, are made as large as the chamber will tolerate. The bullet body forward of that which extends out into the throat and to touch the rifling lead, should be cut close as possible to groove diameter, with as much as a half thousandth under groove being as good as an exact fit, or in most cases up to .oo1 or .002 over groove being just fine. The object of fitting this way, and why it gives the best accuracy possible is that a full chamber neck area will not allow the bullet to tip as it's nose is entering the rifling.