If I remember correctly, there was use of one on "Tracks Across Africa" that worked just fine on the show. I see no reason it wouldn't dispatch animals as Hornady/Ruger claims but I have no desire for one. Brass is going to be less available and more expensive than older .416 offerings with, in my opinion, no significant increase in utility. Also, if you take one to Africa and become separated from your ammunition, lots of luck in getting 416 Ruger ammo there.