It can be done, and with a little practise, maybe even be done well. I've had a sugury on my rt hand and wrist, and currently cannot use it for shooting. I've been doing a little shooting with my left hand, including loading and unloading one handed. At first, it was , "dificult". to say the least, but with some usage, has gotten easer. Notice, I said, "Easer", NOT easy!! I am able to "Trap" the revolver with the loading gate open with my other arm against my body, rotate the cylinder to load, and fire, then open the loading gate with my shooting hand thumb and rotate the cylinder with my shooting hand and push the ejector rod head against anything near to unload. It sounds more complicated than it is, really. But it can be done.
Something I never thought of before, but usefull if a person was wounded on one hand and needed to reload. Maybe it's something we all should work on a bit. Just a thought. Been trying it with my SAA's, the one DA I own, and a couple Semi-auto 1911's to see how I could do a reload if it was necessary. it's possable, but not real easy.
Greeenriver