As I said...there are advantages and disadvantages...in EVERY aspect of life...While economy is good it is chumpchange compared to the rest of the story...I think it is just ridiculous to spend all the money it takes to develop a usable rifle system then chump change the bullet cost, which so many do.
There are lots of ways to reduce costs...maybe the cost of the 45-120 brass is high compared to the 45-70 but when a guy NEEDS a 45-120, what the hell good is something smaller...you can always shoot the smaller case in the longer chamber.
When it comes to big bores,
I don't build one with economy in mind necessarily, my skin is worth a lot more than a few bucks savings on brass cost or bullets.
And if you're thinking about economy there are always rocks and a sling.
I've said it before and here it comes again...their is NO GAME on the North American continent with the exception of Brown and Grizzly bears that the 30-06 won't take cleanly if the hunter is even halfway competent and a whole lot of those bears have been taken with the '06, so anything bigger is just a waste if you look at it from an ecomonical standpoint...BUT...I would rather have a 45-70 and MUCH rather have a 45-120 when push comes to shove...to H*** with economy and the rest of the BS and smoke.
The Powley computer isn't always the best predictive software to use...I use it to check my other software to see if they agree statistically. Powley was also designed for use with IMR powders with a few powders added over the years...it DOES NOT always predict the best powder, only a powder within a certain case capacity and burn rate, THere are at least a half dozen or more other(and much better) powders that are NOT predicted, that can be used in this application.
Once you find what you're looking for THEN the real work begins...load development...no predictive software can tell you what is going to happen when you get out of the armchair and start getting wet.
As far as flexibility goes, what is more flexible that a 45-120 chamber that can shoot a case length range from 2.1"(45-70) to 45-120(3.25") or from the power of a 45 auto to almost a 460 Weatherby....now THAT IS FLEXIBILITY AND ECONOMY.
You just have to open up the box of chocholates and take a bite.
Anyway, this question has been hashed over many times...whatever you decide and for whatever reason, it is
YOUR baby to play with...be happy and enjoy whichever one you choose.
Luck