Depending on the rifle but these two loads are my favorite.
49 grs IMR or AA 4350, CCI 250 primer, Rem case, 117 Sierra flat base Pro Hunter.
52 grs H-4831, CCI BR-2 primer, Rem case, 117 Sierra flat base Pro Hunter or 115 Nosler Partition
52 grs IMR or AA 4350, CCI BR-2 primer, Rem case, 100 gr Nosler Ballistic Tip or Sierra.
These all work great on deer.
This is my varmint load: 52.2 grs IMR or AA 4350 CCI 250 Primer, Rem case, 87 gr Sierra . This is a BOMB on groundhogs. It will scatter pieces.