I normally look for the sweet spot, meaning a bullet weight that will carry velocity, energy, and flat trajectory out to four hundred yards. I am not looking for the 400 yard shot but bullet designed for hunting that does that I feel is the best for the job, and will offer high probability of full penetration. This is for deer and black bear.
.243/6MM = 100 or 105 grain bullet.
6.5 = 140 grain bullet.
.277=140 or 150 grain bullet
.284=160-grain bullet
.30 in my .300 Savage and 30-06 = 165-grain bullet
At one time I was all for the 130-grain bullet in the .270 Winchester and I have killed a number of deer with it. At close range, out to 50-yards, the fast expanding cup & core bullet puts them down fast, but I have spent a fair amount of time tracking deer shot by a brother or myself with 130-grain bullets in the chest cavity that did not exit. That was the reason I went to the 150-grain bullet because I like the addition blood for tracking.
Below are the two images of the same bullet. The jacket was found hanging on the hide next to a large exit hole. I shot this nice buck across a draw at about 100 yards. The deer was moving at a trot down slope. After the shot the buck disappear downhill, and I knew that he was down when I heard his horns clatter on the rocks. Once I got to the location was where the buck was at the time of the shot I started finding blood sign. A few more yards downhill I found a strip of hide and blood. One I spotted the down buck I quit looking for sign.
You can see the core is gone from the jacket. This is typical performance of this old style Norma 150-grain match bullet. I found it to be more effective than the 130-grain bullets in the 270 Winchester.
This Winchester 150-grain Power Point retained 74 percent of its weight and penetrated over 25 inches of deer at 250+ yards. The deer went a short distance.
The bullet expanded to .75 inch.
I have taken a lot of Mule and Blacktail deer with 130-grain bullets from the 270. Most used bullets have been the Remington Bronze Point, Remington C-L, and the Hornady softpoint. Of the three the Hornady is my favorite. I recovered this from a Mule deer taken at about 145 yards. I did not recover the bullet that killed the rattlesnake that almost got me when I was packing the deer out.
The Bronze point normally fragmentized inside the chest cavity. At 13 or 14 I was very impressed with the Bronze point on the first buck I killed with the 270. The bullet hit the deer at close range in the ribs. The bullet fragmentized destroying the lungs, part of the heart, and the front lobe of the live. There were a few fragment cuts inside the rib cage on the far side. The deer might have gone twenty yards.
I like a number of bullets but I have found the design of the Nosler Partition to be ideal with the front portion expanding rapidly and the portion behind the partition penetrating deeply or exiting.
I do not think there is a bullet that is one hundred percent slam-dunk. A friend shot a buck far back in the ribs with a 12 gauge slug. He ended up tracking the buck close to half mile. The slug left a big entrance and exit hole.