Hardly,
Beware the practice of zero at 25 yd then assume you are good to go at a greater distance. Without knowing the bullet you are using, the muzzle velocity, and the distance from bore line to cross hairs it is impossible to give accurate sighting advice.
Here are some examples from the external balistics calculator in RCBS Load 2.88. Each of these are calculated from an initial zero range of 25 yds.
bullet --------------- muzzle vel -- scope ht - down range zero at -- max traj height at yd
40 gr Sierra blitz king 4200 ------- 1.8 in -------- 420 yd ----------- 8.7 in @ 248 yd
40 gr Sierra blitz king 4200 --------1.3 in -------- 345 yd -----------4.7 in @ 198 yd
69 gr Sierra MKHP --- 3200 -------- 1.8 in ------- 320 yd ----------- 5.7 in @ 320 yd
69 gr Sierra MKHP --- 3200 -------- 1.3 in ------- 245 yd -----------2.9 in @ 142 yd
These are extreme examples from each end of the 22-250 performance spectrum, but I think you can see the point I am trying to make here.
A much better practice for sighting in your rifle is: First determine how much rise above sight line you wish to deal with. This will determine the distance for which you will actually sight in the rifle.
For instance if you want 55 gr spitzer bt bullet @ 3700 fps to never be over 2.5 inches above line of sight with a scope mounted 1.5 in above bore line. RCBS Load 2.88 tells us to sight the rifle in to zero at 265 yd.
We can get an initial zero at 35 yd, then check at 100 yd. The rifle should print 1.94 in high at 100 yd. This will give us a max of 2.49 in above line of sight at 156 yd and the bullet should be 2.5 in low at 307 yd.
You still never know for sure until you actually shoot the rifle at 200 and 300 yd and compare your targets to the balistic charts.
I actually zero my 22-250 at 300 yd using the Hornady spire point 60 gr bullet at 3600 fps. I have to hold the cross hairs under the target for shots between 125 and 250 yd, but do not have much hold over until after 350 yd.
If you do not have access to a good balistics program, there is a good one available to download for free at this sight.
http://www.huntingnut.com/pointblank.html