The NEF is notorious for long throats, and with the small size of the 22-250 bullet trying to reach the lands can leave little of the bullet in the case neck,,the chamber neck on my 223 is so long I can't measure it, the bullet falls out of the case before it contacts the lands
That can lead to "run out",, the bullet not being seated straight in the case and not parallel with the case/ bore center lines.
(an THAT was a big deal for accuracy)
I was having trouble with my NEF 223 and 308 until I started paying attention to run out. When I learned to stay near the SAMMI COL and keep thing straight, the groups went from 2xmoa too inside a dime at 100
Instead of trying to reach out to the lands,,Try seating with at least 1 diameter (.224) into the case neck or more, then roll the case watching the bullet tip for wobble or better yet use a gauge.