The .480 Ruger does not have the blistering speed of the .454, but does have the ability to throw substantially heavier projectiles. We must keep in mind that the longer the projectile stays within the target(microseconds)the more energy is released, and conversely the more hydrostatic shock provided which is what creates the wound channels, both permanent, and temporary cavities. Think of a quartering away shot on say, an elk. While we may not be able to differentiate between the penetration on a smaller game animal such as an east coast whitetail, the heavier bullet afforded by the 480 class round is where we are able to see the advantages on larger game. Again, how dead is dead? Bullet placement, and construction are paramount. With these considerations met, the
454 will kill anything that the 480 will. Its all in what is more important to the individual shooter. As I have told my sons, your 22 will kill just as dead as your 44, it just wont be as messy. Remember your ethics, and shoot the gun that you like.