In most case's you can , provided that they fit the chamber , Will they shoot well is a bigger question ?
Thats to be seen , it will depend on what your bore slugs at , Normaly cast bullets will swage down with no problem as they move down the barrel , However there is a chance that pressures will rise slightly and that leading may become an issue .
Some guns do very well with over-sized bullets and some just hate them , only way to know for sure is to try some .
For what its worth , I shoot alot of as-cast .454s in both of my 45LC's and both do very well with them .
stimpy