I had a machine shop drill a .200 hole in mine. It works very well with both 1/8" fuse and also 3/16" quills made from straws.
The hole in mine angles back, and enters the bore .400 (center of hole) from the face of the breech of the bore. If you drill straight in you will have issues hitting light charges.... you may be trying to pierce the projectile instead of the powder bag.
While 2-1/4 ounce blanks are fun for making noise, if you use the same charge behind a ball it will go into orbit. 100 grains of 1F will shoot a lead ball slightly over 100 yards. I have also used 2-1/8" OD concrete filled muffler pipe (6" long). 100 grains will shoot that close to 200 yards.
100 grains in a 2" OD powder bag is a very short charge, which is why you want to angle the vent slightly.
To load a 100 grain bag and get it to seat square is tricky. I wound up taping the bag to the ball with masking tape and loading them together.
To drill the hole, the machine shop use a piece of round stock that fit the bore snugly to hold the barrel. By trial and error, they set the bar up so that the drill hits the center of the vent dimple when the barrel is slid over it until it bottoms out, and so that, with the barrel removed, it hits a point .400 from the end of the round stock.