Well, you've been advised what and where to shoot with that .243. Here is advice where not to shoot: make sure not to hit twigs or branches, because such small, light, fast, and pointed bullets are very easily deflected or destroyed by whatever is between you and the deer.
My favorite deer rifle happens to be a 6mm Rem. Before i acquired it, it has killed 80 head of large deer, elk, and black bears, with the Sierra 85 grain BTHP or the Hornady 100 RN. I continue to use the 100 gr RN, it is the best bullet in this rifle and... i load it slow, and the shape of the bullet gives me a bit more choice to shoot through leaves, etc.