"I am having trouble comprehending the weirdness of the measuring systems."
Ya, and it's just as tough to explain. It's a century old system. (older actually)
Black Powder is/was made all over the world, and you just used what worked from where ever you got it. Back around 1890's an effort was made to standardize the "screening" size of BP.
That's the 2f-3f-4f actual size of the grains. This screening size was for the most part adopted by all, around the 1920's. That way when you bought powder by the screening notation, say 2f or FFG, it would be the same size. At the same time the actual chemicals used differed from region to region and by different makers because of paten issues, so the same volume of powders could in effect weigh differently on a scale. And that still happens today.
(follow so far?)
That's why replica powders say that they equal a certain volume of true BP. Now, on to your delema. It doesn't matter how you measure/weigh your powder charge. You can use your scale if you want, (I'm a loader too).
Let's work up your load, BP and the replicas are WAY different than nitro's it's much more tolerant of variations. You need to keep the Patch and Lube variables the same as we go. We'll use 5 shot groups @ say 50yrds(?) bench if you want. Bore condition IS an issue and some field cleaning should be done between groups.
Start with 55grns on your scale for the .45,
,next round increase by 5 grains (yes 5 full grains) to 60, then to 65-70-75 by the time you reach 80 you should have already begun to see the groups open.
Powders on a scale are usually less than that same charge by volume so your still in the safe range for your gun. Theres only 1 "node" for these things, some guys do find another at really low charges of 20-30 for plinking but does not apply to big game. A gun zeroed at 50 will be about 4-5" low at 100 and still effective for deer kill zones. A patched round ball loses energy quit fast after 125, so keep shot's ethical.
What make is your rifle, CVA? Jukar? T/C?