I think we are discussing nondeforming bullets, which means at handgun velocities primarily?
Number one. If they are going too slow they won't wound large enough to kill quick. So lets get them to kill speed first. At that speed, the flatnoses I offer go through almost any game you'll encounter, chopping a good wound all the way.
For this reason, the concern about deep penetration isn't a concern. If you have concerns about a specific bullet/caliber when ordering an LBT mold and I'll make a reccomendation, as you must understand my offerings are broad, so my answer here is general.
I haven't proven this by testing, but feel certain that the only reasons a faster bullet would penetrate less than a slower one is that the faster one either deforms or expands a little, which naturally makes it push more tissue and slow faster, or causes it to tip a bit, which hurts penetration depth.