I shoot mainly 45's for many years. The main drawback to them is finding "rifle" bullets. Pistol bullets do well out to 150, but that's pushing it. SST's, PR Bullets, and Parker's shoot well and with 110 gr of Pyrodex will shoot nearly a 175yd dead zero. After that, you need to know exactly how far your shot is. There's still enough energy at 200 yds to kill a deer, but the 200gr bullets start falling out of the sky around there. Again, the main drawback is finding "rifle" bullets. JMHO.......