I don't have a handi in .25, but I have his necked up brother the .35 W handi as well as a Ruger M77 .25-06. I love to shoot them both so much I just about have to play rock-paper-scisors with myself to figure out which one to take to the deer woods!
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The .25-06 IMO is probably one of THE most versatile guns for North American game. I have heard many stories of Elk, Moose and other large game taken by
expert hunters and guides; proper bullet placement of course. Flat shooting, plenty of K.O power, and is down-right pleasant to shoot. Many, many coyotes and whitetail have fallen to mine. Wow, I seem to gush over that little cartridge, but man will you be happy with it!!!!!