As already stated, W748, BLC-2, H335 are good with 50 grain bullets in the Handi. In my experience, my best Handi load was using Varget and 50 grain Hornady V-Max with CCI or Winchester primers. I do not like Remingtion primers - absolutely do not use Remington 6 1/2 primers for .223 - these will puncture and are only rated for .22 Hornet.
Paul