I have had this issue before with several different Ruger Security Sixes and an Astra 357 revolver once. It smoothed out eventually for me but still rubbed upon opening and closing.
There should be no rubbing once the cylinder is closed and locked in place, it’s just when the cylinder is opened and closed. It never affected operation of the gun for me; it just rubbed the bluing off the cylinder and forcing cone face (which I did find annoying). I never had this issue with any of the many Colts or Smiths I had.
If the gun is still under warranty, I would contact Ruger if it’s an issue for you. I lived with it until I later traded the revolvers after several years of service with no functional problems.