TommyD...I shot a hog with a 7.5 barreled Ruger Super Blackhawk in 45 LC with a hard cast 250 grain lead SWC over 10.5 grains of Unique, which cleanly went right through both shoulders from 21 yards. No problem at all. DRT. Hog was about 135#'s.
Hogs are not so tough to punch a hole through side to side. Aim small, miss small. They do not take it well in the head (rifle) and double lung or heart shots (rifle/revolver) will get the job done. If after being shot the pig departs for another county, as some will do even though fatally wounded, there is that chance they will bleed internally. The fat layer sometimes closes the wound channel and there is no blood trail. This happens more often with hogs.
Shooting hogs is a lot like shooting squirrels/coons/armadillos/opossum/nuisance animals. In this man's opinion, not too much to it and certainly not the mythical "tough and mean" monsters against taking a bullet that they are touted to be. I will grant them the toughness that even fatally hit, they can and will run a long way before expiring unless something structurally or neurologically vital is disrupted.
Good luck and kill them ALL. There is no "End of Line" with hogs.