Like jmayton said, it depends on the bullet & depends alot. As also stated, 400 yds. is very doable if you have a good shooting 223. After that killing them & seeing them go down can become very different things. I havn't tried them yet, but a good bullet to try would be the new 53V-Max with a BC of .290, it should extend the quick kill range a little further. That BC is better than the 60 V-Max I have been using for years. I sure like it.