The only mold I have shot in the Uberti 45 Colt so far is the LEE 255gr RNFP and the LEE 252gr LSWC. The Uberti did not seem to like the LSWC, but it may have been due to sizing it in a Lyman 450, leaving, as it turns out, the front band unsized. In the future, I am going to run these through my LEE .452 push through sizing die first, then lube them in the 450. I have a 454424 SC and a 452424 DC mold, both purchased used, and could not get acceptable bullets from them last session, so went back make a bunch of the LEE RNFP's at that time to try to rescue my time spent. Hmmm...as it turns out the 452424 and 454424 molds are very different from each other. I do have a 452190 SC mold, but have not tried it yet. I like the RNFP in a revolver load, and with two LEE molds for that bullet, I was able to get a few hundred acceptable bullets in 1 1/2 hrs, and so will probably put off the 452190 for a while.
I've never had any Unique on hand. Historically I have used quite a bit of HERCO and Blue Dot. The HERCO shot ok, but I found greater promise with Blue Dot and with some AA5744 that I originally had on hand for 405Win cast loads, with some apparent success with the 45Colt, as my target shows.
The next step for the Uberti is to turn the bbl to center POI, and then decide which load to sight in for, and file the front sight to raise POI at 25yds. Blue Dot is much less expensive than 5744.
....And then, a lot of shooters like Red Dot for standard loads, so I may pick up a can to try before doing any modifications.
All this work up is delaying my hopes to carry this revolver as a trail gun during our summer hikes this season, but it all has to be taken one step at a time, so I can be confident in it should the need arise.