The principle behind adding a lubricant to your motor fuel is this:
If your engine is consuming NO oil in 3k-4k miles, then there is really nothing lubricating the upper (swept) portion of your cylinder, as the rings are effectively squeegeeing the oil from it on their downward pass. Putting a lubricant in your fuel reduces internal engine friction by lubing that portion of the cylinder.
A two-cycle engine will last every bit as long as a four-cycle in terms of engine revolutions. The reason they've been assigned the "don't last" label is that most run wide full open for the bulk of their lives. Put a four-cycle engine in an application where a friction clutch or torque converter doesn't come on until 7k rpm and it 'won't last' either.
Two cycle lube is a miracle in a bottle. My chainsaw has and will run for years between 10k and 15k RPM with the only thing helping the piston glide through the cylinder being the thin film formed by a 50:1 gas/oil mix.
Hell, I even use it in my bullet lube.
Adding some to your vehicles gas tank shouldn't be a bad thing. The only harm that could be caused may be to the emission system. BUT considering the amount of other contaminants (debris, moisture, etc.) in motor fuels, this is probably negligible.
I've been using the "Marvel Mystery Lube" - not 'Marbles'- as an additive for years, but only in the summer. I've found no gains in the winter. My car will gain about 5% in fuel mileage if that is the only thing I do. With everything that I do, my regular fuel mileage will be 38-42mpg on a 1996 Geo Prizm. I've owned this car since 2002. The first few years it would run 32-35mpg- actually not bad for a 4dr sedan.
Years ago, I worked with a mechanic who'd done a lot of experimenting on his 1973 Olds Delta 88. Using a combination of 'changes', he'd gotten about 22-25mpg (!) out of the 455 cubic inch V-8 -on longer trips. Around town, there was not much noticeable difference and it ran around 15mpg or less.
-Cooler heat range spark plugs -I don't know why this worked for him, but it did and does for me.
-Modified air intake to pick-up warmer air (I've not done this)
-Ran tire pressure at 60psi -despite sidewall rating of 35psi!- (I only run about 5-10psi over sidewall and have for years)
-Underdrive pulley on alternator (my belt drives will not permit this)
-Marvel Mystery Oil additive in fuel and engine oil (yes)
(I believe that he had a B&M shift kit installed that acted as a lock-up converter, but I'm not certain on that.)
Some of those are easy, some more involved, and some may not be as safe.
It is my belief that a clean air filter, jacked up tires, cooler plugs and MM oil have improved my fuel mileage by about 25% for summer driving.
I've gotten over 45mpg a few times by drafting, but it's generally not worth the effort or hassle to other drivers. Mostly a person can idle less, accelerate slower, plan routes a bit better for more consistant speed, and coast (when you decelerate) IN GEAR -not neutral- as the injectors send less fuel. Those will provide the most immediate gains with no mechanical changes.