The standard Blackhawk grip frame is fine for most of us up to around 1000 fps in the 41, 44 & 45 type guns, beyond that they can start to get your attention. The Bisley is much more comfortable & fun to shoot once you get into big bullets & big doses of 2400, H110, AA9, Lil Gun, etc. Doesn't work they way for everyone but a big majority would prefer the Bisley grip frame. Shoot both styles side by side, that makes it easy!
Dick