I'm back again

. This might be better placed in reloading I don't know. I'm looking at a pretty one in SS for $600 if it matters.
Since its intro I have thought this was a great idea, no really, A little big round if you will. A couple more in the cylinder. Hot rounds are touching deer killing territory, light ones are easy plinkers or grouse killers. Coyotes, dispatching wounded big game, no troubles. Expensive to run, but really how much shooting do I really do.
I have heard many arguements against, .22, .22mag, and .38/.357 being notable. I'm not a trapper so .22 honestly is a toy in my world. The .38/.357 are too much for what I foresee, or are they.
Now to the rest of my dimentia. Is it bad to run a mix of .32H&R, and the .327 mag? Would a load using Trailboss in a .327 mag be a better idea? Is the fact this might well be an orphan round be a concern? I do reload but am not what you would call experienced by any stretch. The odd loading is a concern for me, text book "factory loads" don't bother me.
Is there a chance I was kicked in the head by a cow?