These have worked for me for thirty years on deer all over the west, from Texas to Colorado and Utah to Wyoming and Idaho.
Bullet: 130 grain Nosler Partition
Load: 60 Grains of H4831
or
60 Grains of RL 22.
Gets 3,050 fps in 22" barrel. Kills like Thor's Hammer.
I have killed deer as far away as 300 yards (measured wtih laser RF) and as close as 20 feet. The Nosler partition has never let me down, although some other bullets have, namely the 130 Barnes X bullet (no expansion) and the Winchester Power Point factory load (no exit and very little tissue damage on a broadside lung shot at about 150 yds.) With the Nosler Partition, they're dead by the time I get to them. With other bullets I've had to finish them off as they were thrashing and flopping around. I really prefer not to have to see that. So I stick to Nosler Partitions!
Good to the very last shot!