I quit using 30 cals. especially with 150s because they are too hard on the meat. I'm a dedicated meat hunter. If you want the best chance your deer will go down, shoot him in the shoulders with a 150 gr 30 cal bullet and over say 2500 fps. Trouble is you can write off a lot of good hamburger. I avoid totally destroying the shoulder meat by either using heavy slow bullets like the 45-70, or smaller calibers like the 6mm,s.
I always shoot for well behind the shoulder but not so far back as to get behind the diaphram. This is a pretty narrow strip, and sometimes I mess up some meat by shooting a little far forward. I try to err shooting too far forward rather than too far back which will open up the paunch. That does happen occasionally but it isn't a bad a disaster as it seems as the critter usually goes down fast because the bullet still travels near the heart and lungs and usually rips them up. You do end up with loose stomach contents if you shoot too far back, but the way I butcher, I have never had it affect the quality of the meat.
To sum up, if you want your deer on the ground now, shoot him through the shoulders with a fast moving 30 cal. bullet. If you are confident of your bullet placement try to shoot behind the shoulder. He still won't go anywhere, and you may save some hamburger.