Honestly, I've killed two deer within two weeks with my .357 Model 28 a few years ago. Load was a standard Remington 158 gr SJHP(Semi Jacketed Hollow Point). Both deer were shot through the lungs and neither deer went more than 30 yards. So I can't tell you if the Hornady will work well, I've never needed any thing more that the Remmy's. I think any modern expanding .357 is fine. Remington Green Box, Gold Dot, Corbon, Buffalo Bore, etc.